Endocrine Abstracts

Background: The influence of hyperinsulinemia and insulin resistance on thyroid function is debatable. Insulin, as an anabolic hormone, may also play a role in thyroid hypertrophy and nodular goitre development. Some recent reports focus on the possible interplay between thyroid function and glucose status in pregnancy, including gestational diabetes mellitus.Aim: The study aimed to assess the relationship between insulin resistance indices and thyroid f...

Introduction: Topoisomerase II alpha is regarded as the important marker of cellular proliferation. Pituitary tumours are usually benign, but some of them are characterized by rapid growth, high recurrence rate and local invasiveness. Proliferation marker Ki-67 most commonly used in pituitary tumours is not entirely reliable as the indicator of the aggressive growth of the lesion. Topoisomerase II alpha expression assessment may be a valuable tool for identification such pitui...

Background: A significant body of research indicates that transgender and gender-nonconforming persons represent an underserved population susceptible to health care disparities. The attitudes and knowledge of medical doctors toward transgender people have important implications for the future quality of healthcare for transgender patients.Specific Aim: The aim of this study was an assessment of coverage of transgender care issues in training curricula o...

Primary hyperparathyroidism (PHP) diagnosis in clinical practice is based on biochemical blood tests. Since a single parathyroid adenoma causes about 85% of cases, the treatment of choice is parathyroidectomy, preceded by imaging studies. Ultrasound and [99mTc]sestamibi scanning can enable adenoma localization. However, the latter method is of higher sensitivity, especially if combined with anatomical imaging. In some cases, the radiotracer uptake in adenoma tissue ...

Introduction: As observed clinically, the development of pituitary tumours and the probability of their recurrence after neurosurgery tend to be unpredictable. The aim of this work was to evaluate Ki-67 and nuclear and plasmatic prothymosin alpha indices as potential pathological markers to predict the aggressiveness of pituitary adenomas.Material and methods: Ki-67 and prothymosin alpha indices were determined by immunochemistry in specimens excised fro...

Germline AIP gene mutations have been linked with familial isolated pituitary adenomas (FIPA). Inactivating mutations of AIP have also been reported in seemingly sporadic pituitary adenomas, particularly of early onset, aggressive, and GH secreting.Aim: To assess the frequency and type of germline AIP gene mutations in patients with apparently sporadic PMAs.Material: The study included 31 consecutive patients with pituitary macroad...

Up to 5% of all pituitary tumors are hereditary (e.g. due to menin or AIP genes mutations). AIP gene mutations are more common in subjects with acromegaly, less than 30 years old at the onset of disease, and with FIPA family history. The study was aimed at the assessment of the frequency and characteristics of AIP-mutation related tumors in non-selected patients with pituitary macroadenomas.Material and Methods: The study included subsequent 131 patients...

Introduction: During clinical observation the behaviour of pituitary tumours is often unpredictable. The work was aimed at evaluating Ki-67 and pituitary tumour transforming gene (PTTG) indices in pituitary adenomas.Material and methods: The Ki-67 and PTTG indices were determined by immunochemistry in specimens excised from neurosurgically removed pituitary tumours. In fifty two examined patients (30 females and 22 males, mean age 50.5±15.4 years) w...

Measuring of goiter by ultrasonography is one of the generally accepted methods for iodine nutrition assessment. Discordance between previously used and lately proposed thyroid volume (TV) reference values (TVRV) is the subject of discussion and makes it difficult to properly interpret the effects of iodine prophylaxis.Aim: To establish TVRV for Polish schoolchildren population.Material and methods: 2903 schoolchildren aged 6–...

Introduction: In acromegalic patients the incidence of benign and malignant neoplasms, appears to be higher than that in the standard population. Our aim was to evaluate the incidence of tumours in acromegalic patients treated at our Department.Materials and methods: Over the years 1983–2008, 101 acromegalic patients (mean age 51.8±15.4 years), were diagnosed and treated in our Department. Pituitary macroadenoma and microadenoma were stated in ...